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The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we dis...
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The inclusion of nanoparticles dispersed in a hydrophilic matrix is one of the formulation strategies to improve the bioavailability of orally administered Biopharmaceutics Classification System (BCS) class II and IV drugs by increasing their dissolution rate in the intestine. To confirm that the increased dissolution rate results in increased bioavailability, in vitro and in vivo animal experi...
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1 Parkinson’s Disease and Dystonia Research Centre, Tokushima University Hospital, University of Tokushima, Tokushima 770-8503, Japan 2 Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan 3 Department of Neurosurgery, Institute of Health Biosciences, Graduate School of Medical Sciences, Uni...
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parts; an essay on the beginnings of American pharmacology; a bibliographic essay on the history of American pharmacology in academia, government, industry, and charitable foundations; and brief biographies of twenty-six prominent deceased American pharmacologists. The first part traces the evolution of pharmacology from primitive studies, through the work of Magendie and Bernard and the first ...
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Sex chromosome divergence, which follows the cessation of recombination and degeneration of the sex-limited chromosome, can cause a reduction in expression level for sex-linked genes in the heterozygous sex, unless some mechanisms of dosage compensation develops to counter the reduction in gene dose. Because large-scale perturbations in expression levels arising from changes in gene dose might ...
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ژورنال
عنوان ژورنال: Gesnerus
سال: 1965
ISSN: 0016-9161,2297-7953
DOI: 10.1163/22977953-0220304003